彭孝军

个人信息Personal Information

教授

博士生导师

硕士生导师

主要任职:中国化学会创始会士、常务理事,中国化工学会会士

性别:男

毕业院校:大连理工大学

学位:博士

所在单位:化工学院

学科:应用化学. 精细化工. 化学生物学

办公地点:大连理工大学西部校区知顺楼F-202#  
http://peng-group.dlut.edu.cn/

联系方式:大连理工大学西部校区知顺楼F-202 辽宁省大连市高新区凌工路2号,大连116024 课题组网址:http://peng-group.dlut.edu.cn/ E-mail: pengxj@dlut.edu.cn

电子邮箱:pengxj@dlut.edu.cn

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NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy

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论文类型:期刊论文

发表时间:2021-04-12

发表刊物:ADVANCED MATERIALS

卷号:32

期号:11

页面范围:e1907855

ISSN号:0935-9648

关键字:barrier-free rotation; NIR light; photothermal therapy; polymeric nanoparticles; safe intensity light

摘要:Traditional photothermal therapy requires high-intensity laser excitation for cancer treatments due to the low photothermal conversion efficiency (PCE) of photothermal agents (PTAs). PTAs with ultra-high PCEs can decrease the required excited light intensity, which allows safe and efficient therapy in deep tissues. In this work, a PTA is synthesized with high PCE of 88.3% based on a BODIPY scaffold, by introducing a -CF3 "barrier-free" rotor on the meso-position (tfm-BDP). In both the ground and excited state, the -CF3 moiety in tfm-BDP has no energy barrier to rotation, allowing it to efficiently dissipate absorbed (NIR) photons as heat. Importantly, the barrier-free rotation of -CF3 can be maintained after encapsulating tfm-BDP into polymeric nanoparticles (NPs). Thus, laser irradiation with safe intensity (0.3 W cm(-2), 808 nm) can lead to complete tumor ablation in tumor-bearing mice after intravenous injection of tfm-BDP NPs. This strategy of "barrier-free rotation" provides a new platform for future design of PTT agents for clinical cancer treatment.