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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
NIR aza-pentamethine dyes as photosensitizers for photodynamic therapy
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论文类型：期刊论文
发表时间：2021-04-12
发表刊物：DYES AND PIGMENTS
卷号：177
ISSN号：0143-7208
关键字：Aza-pentamethine; NIR; Mitochondria; Photodynamic therapy
摘要：Photodynamic therapy (PDT) as an appealing modality has been used to treat various malignant tumours. Compared with conventional PDT treatment activated by ultraviolet or visible light, near infrared (NIR) light triggered PDT possessing deeper penetration to lesion area and lower photodamage to normal tissue holds great potential for deep-seated tumor. To address these obstacles for PDT treatment, we firstly used aza-indole to modify pentamethine dyes to facilitate a large bathochromic shift of the absorption maximum from 650 nm to 730 nm in the photo-therapeutic window. Interesting, BY-Br have higher molar extinction coefficient than BY-H, allowing BY-Br to absorb more light for enhance its therapeutic effect. Meanwhile, the introduction of bromine atoms has been enhanced reactive oxygen species generation (ROS) after laser irradiation. Furthermore, the new photosensitizer, BY-Br could specifically target to mitochondria, and substantial kill tumor cells through apoptotic pathway upon irradiation.