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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职:中国化学会创始会士、常务理事,中国化工学会会士
性别:男
毕业院校:大连理工大学
学位:博士
所在单位:化工学院
学科:应用化学. 精细化工. 化学生物学
办公地点:大连理工大学西部校区知顺楼F-202#
http://peng-group.dlut.edu.cn/
联系方式:大连理工大学西部校区知顺楼F-202 辽宁省大连市高新区凌工路2号,大连116024 课题组网址:http://peng-group.dlut.edu.cn/ E-mail: pengxj@dlut.edu.cn
电子邮箱:pengxj@dlut.edu.cn
"Off-on'' switching of intracellular singlet oxygen release under biocompatible conditions
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论文类型:期刊论文
发表时间:2021-04-12
发表刊物:CHEMICAL COMMUNICATIONS
卷号:55
期号:92
页面范围:13808-13811
ISSN号:1359-7345
摘要:Precise spatiotemporal control of singlet oxygen generation is of immense importance considering its involvement in photodynamic therapy. In this work, we present a rational design for an endoperoxide which is highly stable at ambient temperatures yet, can rapidly be converted into a highly labile endoperoxide, thus releasing the "stored'' singlet oxygen on demand. The "off-on'' chemical switching from the stable to the labile form is accomplished by the reaction with fluoride ions. The potential utility of controlled singlet oxygen release was demonstrated in cell cultures.