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论文类型： 期刊论文

发表时间： 2004-09-01

发表刊物： Gongneng Cailiao/Journal of Functional Materials

收录刊物： Scopus、EI、PKU、ISTIC

卷号： 35

期号： SUPPL.

页面范围： 2293-2296+2300

ISSN号： 10019731

关键字： Biocompatibility; Biodegradation; Blood vessel prostheses; Cardiovascular surgery; Copolymers; Homopolymerization; Organic coatings, Cardiovascular stent; Glycolide; Polylactides (PLA); Surface coating, Biomaterials

摘要： Polylactides (PLA) and its polymer materials can be degraded by organisms and have good biocompatibility, so that they are widely used as biomaterials and medicinal materials. In this paper, lactide and glycolide were synthesized from lactic acid and glycolic acid respectively; a set of homopolymerizations of lactide with stannous octoate as an initiator and laurly alcohol as a regulator was carried out. We gained a series of homopolymers and copolymers with different monomer proportion. The request of a surface coating of cardiovascular stent is that it can be degraded in 60 to 90 days and has no toxicity, good mechanism property and good biocompatibility with human.