Release Time:2019-07-01  Hits:

Indexed by: Journal Article

Date of Publication: 2019-06-01

Journal: COLLOIDS AND SURFACES B-BIOINTERFACES

Included Journals: EI、PubMed、SCIE

Volume: 178

Page Number: 412-420

ISSN: 0927-7765

Key Words: Zwitterionic polymers; Drug delivery; Biocompatibility; pH-responsiveness

Abstract: As zwitterionic polymers show great promise in drug delivery, hyaluronic acid (HA) was deacetylated and grafted with dodecylamine to prepare a pH-sensitive zwitterionic polymer dHAD used as a carrier for antitumor drugs. The polymer was negatively charged at pH 7.4 and became positive at pH 6.2. In vitro delivery of DOX against MCF-7 cells showed that the blank micelle dHAD had low cytotoxicity and the dHAD-DOX micelles could greatly prohibit the growth of the MCF-7 cells. In addition, the dHAD-DOX micelles had higher cellular uptake, indicating that the micelles were rapidly internalized into the cells via CD44 receptor-mediated endocytosis. The in vivo delivery of DOX to tumor-bearing mice confirmed that the dHAD-DOX micelles greatly inhibited the tumor growth and significantly reduced systemic toxicity of DOX. These results demonstrated that biocompatible pH-responsive zwitterionic dHAD micelles are promising carriers for the delivery of DOX.