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Indexed by:期刊论文

Date of Publication:2018-11-10

Journal:SENSORS AND ACTUATORS B-CHEMICAL

Included Journals:SCIE、Scopus

Volume:273

Page Number:899-905

ISSN No.:0925-4005

Key Words:Mitochondria-targeted; Colorimetric; Imaging; Fluorescence; Environment detection; Sulfur dioxide

Abstract:Sulfur dioxide (SO2), one of active sulfur species (ASS), plays important roles in various physiologies and pathological processes. Hence, it is urgent to monitor the fluctuation of mitochondrial SO2 in vivo. In this work, a novel mitochondria-targeting probe CZ was designed and synthesized based on carbazole derivative, which showed that probe was employed to the detection of SO2 with high selectivity, rapid response as well as naked eyes. Besides, an excellent linear relationship (R-2 = 0.9977) was observed and the detection limit was calculated as low as 0.50411M (3 sigma/k). Surprisingly, with addition of SO2 derivative, fluorescence intensity ratios (F-475 nm/F-607 nm) of probe CZ increased by 1104-fold ranging from 0.007 to 7.73. Owing to its biocompatibility, probe CZ was also successfully employed for monitoring of mitochondrial SO2 by fluorescence confocal microscopy.