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Indexed by:期刊论文

Date of Publication:2016-10-01

Journal:DYES AND PIGMENTS

Included Journals:SCIE、EI、Scopus

Volume:133

Page Number:79-85

ISSN No.:0143-7208

Key Words:NIR fluorescent probe; Human serum albumin; Ultra-low detection limit; Urine

Abstract:Diseases of the kidney, including acute kidney injury, nephritic syndromes, chronic kidney disease, and renal cysts, are accompanied by a series of characteristic clinical features. Human Serum Albumin (HSA) is regarded as an important biomarker for early warning of kidney diseases among them. To the best of our knowledge, although some fluorescent probes of HSA had reported in blood plasma under high concentrations of HSA, most of them could not reach the detection sensitivity of low concentrations of HSA in urine. In this work, an NIR fluorescent probe NIR-HSA for HSA based on TICT mechanism is reported, which can used in solution detection with 8.83-fold fluorescence enhancement, rapid response (completed within 5 s), excellent sensitivity (DL 26.16 nM), and excellent stability. In human urine detection, NIR-HSA clearly demonstrated perfect recovery property, and good potential to be applied to detect trace HSA for warning of critical diseases. (C) 2016 Elsevier Ltd. All rights reserved.