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A Ratiometric Near-Infrared Fluorescent Probe for Hydrazine and Its in Vivo Applications

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Indexed by:期刊论文

Date of Publication:2013-08-02

Journal:ORGANIC LETTERS

Included Journals:SCIE、PubMed、Scopus

Volume:15

Issue:15

Page Number:4022-4025

ISSN No.:1523-7060

Abstract:Based on modulation of the conjugated polymethine pi-electron system of a cyanine dye derivative, a ratiometric near-infared fluorescent probe (Cy7A) for hydrazine (N2H4) has been designed and synthesized. Cy7A can be selectively hydrazinolysized with great changes in its fluorescent excitation/emission profiles, which makes it possible to detect N2H4 in water samples and living cells and, for the first time, visualize N2H4 in living mice.

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