Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2012-12-14

Journal: CHEMICAL COMMUNICATIONS

Included Journals: Scopus、PubMed、SCIE

Volume: 48

Issue: 96

Page Number: 11766-11768

ISSN: 1359-7345

Abstract: Rlyso, a highly selective and sensitive pH sensor, can stain lysosomes with a novel lysosome-locating group, methylcarbitol. Rlyso was successfully used to detect lysosomal pH changes during apoptosis or induced by chloroquine while avoiding the "alkalizing effect" on lysosomes of current lysosomal probes with nitrogen-containing sidechains.