Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2011-04-26

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Included Journals: PubMed、EI、SCIE、Scopus

Volume: 50

Issue: 18

Page Number: 4180-4183

ISSN: 1433-7851

Key Words: cell cycle; DNA; fluorescent probes; imaging agents; nucleus staining

Abstract: Seeing red: DEAB-TO-3 shows a large fluorescence enhancement upon binding to native DNA and a distinct selectivity for double-stranded DNA over total RNA. As a red fluorescent live-cell-permeant DNA minor groove binder, DEAB-TO-3 is promising for highly sensitive DNA detection in vitro and nucleus-specific imaging and DNA quantification in vivo (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.