location： Current position: Home >> Scientific Research >> Paper Publications

Mild and Highly Enantioselective Vinylogous Aldol Reaction of Brassard's Diene with Aromatic Aldehydes by Combined Lewis Acid Catalyst

Hits:

Indexed by:期刊论文

Date of Publication:2010-08-06

Journal:JOURNAL OF ORGANIC CHEMISTRY

Included Journals:SCIE、EI、PubMed

Volume:75

Issue:15

Page Number:5326-5329

ISSN No.:0022-3263

Abstract:The combined Lewis acid catalytic system, generated from (R)-1,1'-bi-2-naphthol [(R)-BINOL], Ti(O-i-Pr)(4), H2O, and lithium chloride, effectively catalyzed the enantioselective vinylogous aldol reaction of Brassard's diene with aromatic aldehydes affording the (Z)-delta-hydroxyl-alpha,beta-unsaturated esters exclusively in good yields with excellent enantioselectivities (90-99% ee) under mild conditions. A Lewis acid Lewis acid bifunctional working model was proposed for the catalytic process based on some control experiments.

Pre One:Friedel-Crafts-Type Allylation of Nitrogen-Containing Aromatic Compounds with Allylic Alcohols Catalyzed by a [Mo3S4Pd(eta(3)-allyl)] Cluster

Next One:Highly Efficient and Regioselective Allylation with Allylic Alcohols Catalyzed by [Mo3S4Pd(eta(3)-allyl)] Clusters
Recommended Ph.D.Supervisor Recommended MA Supervisor Institutional Repository Personal Page

Address: No.2 Linggong Road, Ganjingzi District, Dalian City, Liaoning Province, P.R.C., 116024

Click : times
  • MOBILE Version
    •
    Open time:..
    The Last Update Time:..

    Mobile phone sweep