孙文，大连理工大学精细化工全国重点实验室研究员、博士生导师, 获基金委青年科学基金项目 (A 类)（原国家杰青）、基金委青年科学基金项目 (B 类)（原国家优青）项目资助。2017年12月毕业于德国马普高分子研究所 (Max-Planck-Institute for Polymer Research)，获化学博士学位。2018年3月加入大连理工大学精细化工国家重点实验室，2021年起任研究员，博士生导师。目前担任精细化工国家重点实验室主任助理、中国感光学会光学传感与诊疗专委会副秘书长、中国化工学会精细化工专业委员会青年委员、大连市精细化工学会秘书长。入选“辽宁省百千万人才工程” 培养计划。主持国家自然科学基金面上和青年项目、教育部领军人才团队项目、辽宁省重点研发计划、辽宁省和大连市自然科学基金等多项纵向基金。

针对生命、医学中关键标志物分析检测及疾病精准治疗的关键科学问题，近年来开展了以功能染料为核心用于疾病诊断及光驱动治疗的研究工作。共发表SCI论文90余篇。以第一或通讯作者在Nat. Chem.、J. Am. Chem. Soc. (3篇)、Angew. Chem. Int. Ed (10篇)、Adv. Mater. (7篇)、Matter、Adv. Funct. Mater. (9篇)、Adv. Sci. (3篇)、Biomaterials (6篇)、 Chem. Rev. 、 Accont. Chem. Res. 、Prog. Mater. Sci.、 Coordin. Chem. Rev. 等国际知名学术期刊上发表研究成果。2篇文章入选Hot paper, 9篇入选ESI高被引，多篇文章分别被JACS、Adv. Mater.和Adv. Sci.杂志选为封面/内封面。SCI引用16000余次, H 因子67。入学全球前2%顶尖科学家-终身影响力榜单（2025年）。

获2026年中国感光学会自然科学一等奖（排1），2025年日内瓦国际发明奖金奖（排1），2019年中国石油和化学工业联合会科技进步一等奖（排5），2025年辽宁杰出科技青年奖，2023年侯德榜化工科学技术青年奖，2023年兴辽英才计划青年拔尖人才，2024年 J. Mater. Chem B.新锐科学家，2024年 Chem. Comm.新锐科学家。

学术兼职：担任Frontiers in Chemistry (IF: 5.22,  JCRQ2) 期刊副主编，Smart Molecules、Chinese Chem. Letter、《应用化学》及中南大学学报（国际版）编委。

 Selected Publications

2026

1. Scintillon-Mimicking Mechanoluminescence for Theranostic Applications. X. Xie, C. Yang, J. Liu, Q. Ning, Z. Wu, S. Wang, J. Cao, X. Chen, M. Li; Kam W. Leong, F. Chen*, D. Shao*, W. Sun* J. Am. Chem. Soc. 2026, 148, 13902.

2. Acoustic-To-ElectronicTransduction: Ultrasound-Triggered Reductive Elimination of Platinum (IV) Prodrugs for Deep-Tissue Metallodrug Activation. X. Cheng, X. Zhou,Y. Fang,Y. Yin, D. Fan, X. Huang,T. Zhu, H. Guo, J. Liu, Z. Cheng, F. Chen,* W. Sun,* W. Zeng* J. Am. Chem. Soc. 2026, 148, 41062.

3. Self-Assembled Ruthenium Complexes with Sonobleaching Ligand for Enhanced Tumor Penetration and Immunogenic Sonotherapy, M. He, X. Cheng, L. Zhang, Z, Zhang, C. Liu, X. Zeng, Z. Ma, J. Fan, X. Peng, W. Sun*Adv. Mater., 2026, 38(13): e23608.

5. Self-Adaptive Charge Transfer States in Aqueous Solutions Promote Fast Intersystem Crossing in a Photosensitizer for Tumor Inhibition, R. Wang, X. Xia, Z. Zhang, T. Qiu, W. Tang, D. Zhou, X. Zeng, J. Fan, X. Peng, W. Sun*Adv. Mater., 2026, 38(42): e73793.

5. Excited-State Structural Distortion of Pentamethine Chains Enhances Singlet Oxygen Generation as a Photoimmunotherapeutic Agent. R. Wang, T. Qiu, W. Tang, Z. Zhang, Y. Hu, D. Zhou, X. Zeng, J. Fan, X. Peng, Wen Sun*. Angew. Chem. Int. Edit. DOI: 10.1002/anie.6505397.

6. Protein-Anchored Near-Infrared Heptamethine Cyanine Photosensitizer with Ultralong Retention for Phototherapy of Large Tumors. Y. Han, M. He, L. Zhang, C. Liu, Y. Qiao, Y. Li, J. Fan, W. Sun*, X. Peng. Biomaterials, 2026, 329, 123914.

7. Activated Fluorescent Probe for Long-Term Imaging and Surgical Navigation via Enzyme-Mediated Fluorogenic Reaction and Self-Assembly. T. Liu⁺, X. Xia⁺, W. Liu, C. Lv, C. Liu, R. Wang, J. Du, J. Fan, W. Sun*, X. Peng. Adv. Funct. Mater, 2026, 36, e22069.

2025

1. A Reusable Substrate for Capture and Red Light-Responsive Release of Circulating Rare Cells with High Cytoactivity. Z. Su, R. Wang, D. Xi, J. Zuo, Z. Zhang, W. Liu, X. Zeng, J. Du, J. Fan, X. Peng, W. Sun*, Angew. Chem. Int. Edit. 2025, 64, e202516070.

2. Engineering Supramolecular Assemblies via Metal–Metal Interactions for Biological Applications. M. He, X. Zhou, Y. He, J. Fan, X. Peng, J. S. Kim, W. Sun*, Angew. Chem. Int. Edit. 2025, 64, e16383.

3. Cyclometalating Ligand Affords NIR Absorption in Ruthenium Complexes for Type-I Photodynamic Therapy. Z. Zhang, X. Zeng, X. Zhou, Z. Ma, M. He, D. Zhou, S. Long, J. Fan, X. Peng, W. Sun*, Angew. Chem. Int. Edit. 2025, 64, e202512296.

4. Self-Assembled Ruthenium–Amino Acid Conjugates Enable Endoplasmic Reticulum–Nucleus Cascade Targeting for Cell Pyroptosis and DNA Destruction. Z. Ma, M. He, Z. Zhang, X. Zeng, S. Wang, C. Peng, J. Du, J. Fan, X. Peng, W. Sun*, Adv. Mater. 2025, 37, e08713.

5. Nonconjugated Structural Distortion Promoting the Formation of NIR Triplet States in Phenothiazine Dyes for Cancer Photoimmunotherapy. X. Xia, R. Wang, Y. Hu, S. Long, W. Sun*, J. Fan*, X. Peng, Angew. Chem. Int. Edit. 2025, 64, e202507157.

6. Biomimetic Chlorosomes: Oxygen-Independent Photocatalytic Nanoreactors for Efficient Combination Photoimmunotherapy. F. Chen, H. Huang, F. Zhang, R. Wang, L. Wang, Z. Chang, L. Cao, W. Zhang, L. Li, M. Chen, D. Shao, C. Yang*, W.-f. Dong*, W Sun*, Adv. Mater. 2025, 147, 101347.

7. Albumin-Chaperoned Deep-NIR Triarylmethane Dyes for High-Contrast In Vivo Imaging and Photothermal Therapy. X. Zhang, M. Liu, Y. Hu, X. Wang, R. Wei, C. Yao, C. Shi, Y. Qiu, T. Yang, X. Luo, J. Chen*, W. Sun*, H. Chen*, X. Qian*, Y. Yang*. Adv. Mater. 2025, 37, 2411515.

8. Photocaged Fluorescent Chemosensor for Sequential Activation and Precise Monitoring of Mitochondrial ATP.  Y. Hu, X. Xia, R. Wang, H. Wang, J. Du, J. Fan, X. Peng, W. Sun*, Adv. Funct. Mater. 2025, 36, e13664.

9. A CYP2J2-Activated Photosensitizer with In Situ Enzyme Anchoring Induces Pyroptosis in Cancer Therapy. X. Xia, R. Wang, Y. Hu, H. Gu, W. Sun*, J. Fan*, X. Peng, Adv. Funct. Mater. 2025, 35, 2422823.

2024

1. Phototherapeutic nanoagents for cancer immunotherapy. M. He, M. Xiao, R. Wang, J. Fan, X. Peng, W. Sun*. Prog. Mater. Sci. 2025, 147, 101347.

2. Sonoinduced Tumor Therapy and Metastasis Inhibition by a Ruthenium Complex with Dual Action: Superoxide Anion Sensitization and Ligand Fracture. M. He, Z. Ma, L. Zhang, Z. Zhao, Z. Zhang, W. Liu, R. Wang, J. Fan, X. Peng. W. Sun*J. Am. Chem. Soc. 2024, 146, 25764. (Front Cover)

3. Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy. W. Liu, S. He, X. Ma, C. Lv, H. Gu, J. Cao, J. Du, W. Sun*, J. Fan*, X. Peng. Angew. Chem. Int. Edit. 2024, e202411802.

4. Leveraging Radiation-triggered Metal Prodrug Activation Through Nanosurface Energy Transfer for Directed Radio-chemo-immunotherapy. F. Ruan, H. Fang, F. Chen*, X. Xie, M. He, R. Wang, J. Lu, Z. Wu, J. Liu, F. Guo, W. Sun*, D. Shao*. Angew. Chem. Int. Edit. 2024, e202317943.

5. Photoresponsive Ru Metalloprodrug Assemblies: Red‐Light‐Controlled Self‐Delivery Systems for Enhanced Anticancer Phototherapy. X. Zeng, Z. Zhang, Y. Huang, J. Fan, X. Peng, S. Wu*, W. Sun*. Adv. Funct. Mater. 2024, 34, 2315885.

6. Supramolecular metallopolymer for hypoxia-activated ruthenium complexes delivery and smart chemo-photodynamic therapy. M. He, Z. Ma, Z. Zhang, L. Zhang, S. Zhang, R. Wang, X. Leng, Y. Li*, J. Fan. W. Sun*, X. Peng. Sci. China. Chem. 2024, 67, 3875-3885.

7. Mesoporous Cerium Oxide Nanoenzyme for Efficacious Impeding Tumor and Metastasis via Conferring Resistance to Anoikis. Y. Wang, L. Ding, J. Feng, Z. Lin, H. Yao, X. You, Z. Zhang, W. Sun*, Y. Liu, P. Wang, Biomaterials 2024, 314, 122876.

8. Photodynamic therapy promotes hypoxia‐activated nitrogen mustard drug release. R. Wang, M. He, Z. Zhang, T. Qiu, Y. Xi, X. Zeng, J. Fan, W. Sun*, X. Peng. Smart Molecules 2024, 2, e20230014.

9. Se-substituted pentamethine cyanine for anticancer photodynamic therapy mediated using the hot band absorption process. W. Liu, Y. Hou, W. Liu, R. Wang, S. He, X. Xia, C. Lv, H. Gu, Q. Yao, Q. Pan, Z. Su, D. Zhou, W. Sun*, J. Fan*, X. Peng. Chinese Chem. Lett. 2024, 109631.

2023

1. In Vivo Metallophilic Self-assembly of a Light-activated Anticancer Drug. X. Zhou, P. Wang, V. Ramu, L. Zhang, S. Jiang, X. Li, S. Abyar, P. Papadopoulou, Y. Shao, L. Bretin, M. A Siegler, F. Buda, A. Kros, J. Fan, X. Peng, W. Sun*, S. Bonnet*. Nat. Chem. 2023, 15, 980-987.

2. Near-Infrared Light-Activated Ruthenium Complex-based Photocage for Cancer Phototherapy. G. He, M. He, R. Wang, X. Li, H. Hu, D. Z. Wang, Y. Lu, N. Xu, J. Du, J. Fan, X. Peng, W. Sun*. Angew. Chem. Int. Edit. 2023, 62, e202218768 (Front Cover).

3. Liposomal Enzyme Nanoreactors based on Nanoconfinement for Efficient Anti-Tumor Therapy. R.Wang,Y.Yu, M. Gai, A. M. Maroto, S. Morsbach, X. Xia, M. He, J. Fan, X. Peng, K. Landfester*, S. Jiang*, W. Sun*. Angew. Chem. Int. Edit. 2023, 62, e202308761.

4. Cyclic Ruthenium-Peptide Conjugates as Integrin-Targeting Photoactivated Chemotherapy Prodrugs for the Treatment of Brain Tumors. L. Zhang, P. Wang, X. Zhou, L. Bretin, X. Zeng, Y. Husiev, E. Rivas, L. Wijaya, T. Biver, S. Dévédec, W. Sun,* S. Bonnet*. J. Am. Chem. Soc. 2023, 145, 14963-14980.

5. A Fluorescent Chemosensor for Long-Term Tracking of Cancer Cell Metastasis and Invasion via Enzyme-Activated Anchoring. T. Liu, X. Xia, R. Wang, X. Rong, Z. Su, J. Du, J. Fan, X. Peng, W. Sun*. Adv. Funct. Mater. 2023, 33, 2304347.

6. The Construction of Polyphotocage Platform for Anticancer Photochemotherapy. M. He, R. Wang, R. Zhang, P. Miao, P. Wang*, Z. Wei, X. Leng, Y. Li*, J. Fan, X. Peng, W. Sun*. Adv. Funct. Mater. 2023, 33, 2300780.

7. Heptamethine Cyanine Dyes with Ultra-efficient Excited-state Nonradiative Decay for Synergistic Photothermal Immunotherapy. X. Xia, C. Shi, S. He, R. Wang, Z. Zhang, Y. Hu, J. Cao, T. Liu, D. Zhou, W. Sun*, J. Fan*, X. Peng. Adv. Funct. Mater. 2023, 33, 2300340.

8. The chronological evolution of fluorescent GPCR probes for bioimaging. Y. Wu, B. Zhang*, H. Xu, M. He, X. Deng, L. Zhang, Q. Dang, J. Fan, Y. Guan*, X. Peng, W. Sun*. Coordin. Chem. Rev., 2023, 480, 215040.

9. Carrier‐Free ATP‐Activated Nanoparticles for Combined Photodynamic Therapy and Chemotherapy under Near‐Infrared Light. Z. Su, D. Xi, Y. Chen, R. Wang, X. Zeng, T. Xiong, X. Xia, X. Rong, T. Liu, W. Liu, J. Du, J. Fan, X. Peng, W. Sun*. Small 2023, 19, 2205825.

10. Recent Progress of Self-Immobilizing and Self-Precipitating Molecular Fluorescent Probes for Higher-Spatial-Resolution Imaging.J. Yan, H. Liu, Y. Wu, B. Niu, X. Deng, L. Zhang, Q. Dang, Y. Wang, X. Lu, B. Zhang*, W. Sun*.  Biomaterials, 2023, 301, 122281.

2022

1. Gene Therapy of Brain Cancer by Drug Delivery Nanocapsules. X.-Q. Zhou, R. Wang, W Sun*, S. Bonnet*. Matter, 2022, 3, 2502. 

2.Tumor-microenvironment triggered signal-to-noise boosting nanoprobes for NIR-IIb fluorescence imaging guided tumor surgery and NIR-II photothermal therapy. P. Wang, J. Li, M. Wei, R. Yang, K. Lou, Y. Dang. W. Sun*, F. Xue, X. Liu. Biomaterials, 2022, 287, 121636.

3. H-Aggregates of Prodrug-Hemicyanine Conjugate for Enhanced Photothermal Therapy and Sequential Hypoxia-Activated Chemotherapy, X. Li, M. Yang, J. Cao, H. Gu, W. Liu, T. Xia, W. Sun*, J. Fan*, X. Peng. ACS Mater. Lett. 2022, 4, 724-732.

4. A Glutathione Activatable Pro-drug-photosensitizer for Combined Chemotherapy and Photodynamic Therapy.Y. Yang, Y. Zhang, R. Wang, X. Rong, T. Liu, X. Xia, J. Fan, W Sun*, X. Peng. Chinese Chem. Lett. 2022, 33, 4583-4586.

5. Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement. M. He, R. Wang, P. Wan, H. Wang, Y. Cheng, P. Miao, Z. Wei, X. Leng, Y. Li*, J. Du, J. Fan, W. Sun*, and X. Peng. Biomacromolecules 2022, 23,1733-1744. (Front Cover)

6. Red-Light-Triggered Self-Destructive Mesoporous Silica Nanoparticles for Cascade-Amplifying Chemo-Photodynamic Therapy Favoring Antitumor Immune Responses. Y. Yang, F. Chen, N. Xu, Q.Yao, R. Wang, X. Xie, F. Zhang, Y. He e, D. Shao *, W. Dong, J. Fan, W. Sun *, X. Peng. Biomaterials, 2022, 281, 121368.

7. A Sulfur-Substituted Hemicyanine for Cancer Photothermal Therapy with-out Influence of Intracellular Viscosity. X. Xia, R. Wang, Y. Hu, Q. Yao, S. Long, W. Sun*, J. Fan*, X. Peng. Science China Chemistry, 2022, 65, 821-828. 

8. A Glutathione Activatable Photosensitizer for Combined Photodynamic and Gas Therapy under Red Light Irradiation. R. Wang, X. Xia, Y. Yang, X. Rong, T. Liu, Z. Su, X. Zeng*, J. Du, J. Fan, W. Sun*, X. Peng. Adv. Healthcare Mater. 2022, 11，2102017.

2021

1. Strong π−π Stacking Stabilized Nanophotosensitizers: Improving Tumor Retention for Enhanced Therapy to Large Tumor in Mice. D. Xi, N. Xu, X. Xia, C. Shi, X. Li, D. Wang, S. Long, J. Fan, W. Sun*, X. Peng*. Adv. Mater. 2022, 34, 2102797.

2. A Sequential Dual-Model Strategy Based on Photoactivatable Metallopolymer for On-Demand Release of Photosensitizers and Anticancer Drugs. M. He, G. He, P. Wang, S. Jiang, Z. Jiao, D. Xi, P. Miao, X. Leng, Z. Wei,* Y. Li,* Y. Yang, R. Wang, J. Du, J. Fan, W. Sun,* X. Peng. Adv. Sci. 2021, 8, 2103334. 

3. Photoresponsive Metallopolymer Nanoparticles for Cancer Theranostics. M. He, F. Chen, D. Shao, P. Weis, Z. Wei, and W. Sun*. Biomaterials 2021, 275, 120915.

4. Red-Light-Responsive Ru Complex Photosensitizer for Lysosome Localization Photodynamic Therapy. G. He, N. Xu, H. Ge, Y. Lu, R. Wang, H. Wang, J. Du, J. Fan, W. Sun*, X. Peng. ACS Applied Materials & Interfaces. 2021, 13,19572-19580.

Before 2020

1. A photosensitizer-inhibitor conjugate for photodynamic therapy with simultaneous inhibition of treatment escape pathways. M. Xiao, J. Fan*, M, Li, F, Xu, X. Zhao, D. Xi, H. Ma, Y. Li, J. Du, W. Sun*, X.Peng. Biomaterials.2020, 257, 120262.

2. Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem ROS Generation. S. Jiang, M. Xiao, W. Sun*, D. Crespy, V. Mailänder, X. Peng, J. Fan,* K. Landfester* Angew. Chem. Int. Edit. 2020, 59, 2-11. (Hot paper)

3. Protein nanoparticles containing Cu(II) and DOX for efficient chemodynamic therapy via self-generation of H₂O₂. R. Cao, W. Sun*,Z. Zhang, X. Li, J. Du, J. Fan, X. Peng. Chinese Chem. Lett. 2020. 31, 3127-3130.

4. The Self-Assembly of a Cyclometalated Palladium Photosensitizer into Protein-Stabilized Nanorods Triggers Drug Uptake In Vitro and In Vivo. X. Zhou, M. Xiao, V. Ramu, J. Hilgendorf, X. Li, P. Papadopoulou, M. Siegler, A. Kros, W. Sun*, S. Bonnet*. J. Am. Chem. Soc.2020, 142, 10383.

5. NIR Light‐Driving Barrier‐Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy. D. Xi, M. Xiao, J. Cao, L. Zhao, N. Xu, J. Fan, K. Shao, W. Sun*, X. Yan, X. Peng*.  Adv. Mater.  2020, 32, 1907855.

6. Activity-Based Sensing and Theranostic Probes Based on Photoinduced Electron Transfer. W. Sun, M, Li, J. Fan, X. Peng. Accounts. Chem. Res.2019, 52, 2818.

7. Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti-Metastatic Immunotherapy. Z. Wang, F. Zhang, D. Shao*, Z. Chang, L. Wang, H. Hu, X. Zheng, X. Li, F. Chen, Z. Tu, M. Li, W. Sun*, L. Chen, W. Dong*. Adv. Sci. 2019,1901690.

8. Boron Dipyrromethene Nanophotosensitizers for Anticancer Phototherapies. W. Sun, X. Zhao, J. Fan,* X. Peng. Small 2019, 1804927. (highlighted by Advanced Science News)

9. Red-Light-Controlled Release of Drug-Ru Complex Conjugates from Metallopolymer Micelles for Phototherapy in Hypoxic Tumor Enviroment. W. Sun, Y. Wen, R. Thiramanas, M. Chen, J. Han, N. Gong, M. Wagner, S. Jiang, M. S. Meijer, S. Bonnet, H.-J.Butt, V. Mailänder,* X.-J. Liang,* S. Wu*. Adv. Funct. Mater. 2018, 1804227.

10. An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo. W. Sun, S. Li, B. Häupler, J. Liu, S. Jin, W. Steffen, U. S Schubert, H.-J. Butt, X.-J. Liang,* S. Wu* Adv. Mater. 2017, 29, 1603702.

11. Recent Development of Chemosensors Based on Cyanine Platforms. W.  Sun, S. Guo, C. Hu, J. Fan, X. Peng* Chem. Rev. 2016, 116, 7768-7817.

12. Ruthenium-Containing Block Copolymer Assemblies: Red-Light-Responsive Metallopolymers with Tunable Nanostructures for Enhanced Cellular Uptake and Anticancer Phototherapy. W. Sun, M. Parowatkin, W. Steffen, H.-J. Butt, V. Mailänder, S. Wu*. Adv. Healthcare Mater 2016, 5, 467-473.