Indexed by:期刊论文
Date of Publication:2017-01-20
Journal:ORGANIC LETTERS
Included Journals:SCIE
Volume:19
Issue:2
Page Number:316-319
ISSN No.:1523-7060
Abstract:The catalyst system of Pd(TFA)(2)/(S,S)-diPh-pyrox is reported to promote the highly efficient enantioselective oxidative cascade cyclization of alkene-tethered aliphatic acrylamides under mild aerobic conditions. A series of pyrrolizidine derivatives have been synthesized in good yield and excellent enantioselectivity. Deuterium-labeling experiments have revealed that the reaction proceeded through an anti-aminopalladation (anti-AP) pathway with high selectivity. The transition states for the anti-AP step have been calculated to account for the observed enantioselectivity.
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Associate Professor
Supervisor of Master's Candidates
Gender:Female
Alma Mater:辽宁师范大学
Degree:Doctoral Degree
School/Department:化工海洋与生命学院
Discipline:Applied Chemistry. Chemical Engineering. Fine Chemicals
Contact Information:chyangli@dlut.edu.cn
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