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个人信息Personal Information
副教授
博士生导师
硕士生导师
性别：男
毕业院校：浙江大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 有机化学
办公地点：大连市甘井子区凌工路2号
大连理工大学西部校区E座406室
联系方式：15040537236 zhangtiexin@dlut.edu.cn
电子邮箱：zhangtiexin@dlut.edu.cn
Copper-catalyzed synthesis of indolyl diketones via C-H oxidation/diacylation of indoles with arylglyoxal hydrates
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论文类型：期刊论文
发表时间：2017-08-07
发表刊物：ORGANIC & BIOMOLECULAR CHEMISTRY
收录刊物：SCIE、EI、PubMed
卷号：15
期号：29
页面范围：6185-6193
ISSN号：1477-0520
摘要：An expedient protocol for Cu-catalyzed C-H oxidation/diacylation of indoles with arylglyoxal hydrates to construct indolyl diketones is developed. This methodology exhibits the synthetic utility of the synthesis of an indole-alkaloid 1,2-di(1H-indol-3-yl) ethane-1,2-dione and offers a straightforward means to produce different indolyl nitrogen-containing heterocycles such as indolyl quinoxaline, indolyl hydantoin and indolyl imidazole in high yields. Preliminary mechanistic studies indicate that two proposed pathways are involved in this process.