Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2009-10-12

Journal: SENSORS AND ACTUATORS B-CHEMICAL

Included Journals: Scopus、EI、SCIE

Volume: 142

Issue: 1

Page Number: 191-196

ISSN: 0925-4005

Key Words: Fluorescence; Chemosensor; Imaging; Mercury ion; Living cells; Anions

Abstract: A fluorescent chemosensor, B2, for Hg(2+) containing a BODIPY fluorophore and carboxyl-thiol metal-bonding moieties was described. B2 exhibits selective fluorescence enhancement (123-fold) toward Hg(2+) over other metal ions. Especially, the fluorescence enhancement was unaffected by anions existing in environment and organism. B2 shows high sensitivity to Hg(2+) in a concentration of ppb range with detection limit of 77 nM. B2-ester, the membrane-permeable ethyl ester, is able to be hydrolyzed to B2 in vivo, and successfully applied to image intracellular Hg(2+) in living cells. (C) 2009 Elsevier B. V. All rights reserved.