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Indexed by:期刊论文
Date of Publication:2009-08-01
Journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Included Journals:SCIE、PubMed、Scopus
Volume:19
Issue:15
Page Number:4139-4142
ISSN No.:0960-894X
Key Words:Bisintercalator; Dinuclear Iron(III) complex; Artificial nuclease
Abstract:Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage. (C) 2009 Elsevier Ltd. All rights reserved.