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阳离子环肽对Caco-2细胞膜超微结构与渗透性的影响

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Indexed by:期刊论文

Date of Publication:2014-01-01

Journal:药学学报

Included Journals:Scopus、PKU、ISTIC、CSCD

Volume:49

Issue:7

Page Number:1062-1068

ISSN No.:0513-4870

Key Words:Caco-2细胞膜; 阳离子环肽; 胰岛素

Abstract:本文考察了阳离子环肽处理后Caco-2细胞膜表面的微观形态变化,
   研究了细胞膜形态变化与亲水性大分子药物胰岛素跨膜渗透性的关系。采用原子力显微镜轻敲模式, 在大气条件下对Caco-2细胞膜进行实时观察,
   发现阳离子环肽TD-34 (ACSSKKSKHCG)作用于Caco-2细胞膜后, 细胞膜表面失去原有的平整性和光滑性,
   细胞膜表面粗糙度较未处理组提高近一倍, 胰岛素跨Caco-2细胞膜表观渗透系数增大, 为原来的2.5倍。研究表明,
   原子力显微镜可用于阳离子环肽作用后细胞膜表面微观形态变化的实时观测,
   阳离子环肽通过增加Caco-2细胞膜流动性促进了胰岛素通过胞吞途径的跨膜吸收。

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